Aminocarboxylic acid derivative and medicinal use thereof

Details Aminocarboxylic acid derivative and medicinal use thereof Aminocarboxylic acid derivative and medicinal use thereof

C - Chemistry, Metallurgy

07

C

C07C 229/14 (2006.01) A61K 31/12 (2006.01) A61K 31/166 (2006.01) A61K 31/197 (2006.01) A61K 31/215 (2006.01) A61K 31/397 (2006.01) A61K 31/4035 (2006.01) A61K 31/41 (2006.01) A61K 31/437 (2006.01) A61K 31/4409 (2006.01) A61K 31/4412 (2006.01) A61K 31/4439 (2006.01) A61K 31/4725 (2006.01) A61K 31/55 (2006.01) A61K 45/00 (2006.01) A61P 1/04 (2006.01) A61P 3/10 (2006.01) A61P 7/00 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/04 (2006

Patent

CA 2591399

A compound represented by the general formula (I), a salt thereof, an N-oxide form thereof, a solvate thereof, or a prodrug of any of these; and a drug containing any of these. (I) (In the formula, all the symbols are as defined in the description.) The compound represented by the general formula (I) has the ability to combine with an S1P receptor (especially EDG-1, EDG-6, and/or EDG-8). It is useful for the prevention and/or treatment of rejection reactions to transplantation, graft versus host diseases, autoimmune diseases, allergic diseases, neurodegenerative diseases, etc.

La présente invention décrit un composé de formule générale (I), un sel dudit composé, un N-oxyde dudit composé, un solvate dudit composé, ou une prodrogue de n'importe laquelle de ces substances, ainsi qu~un médicament contenant l'une quelconque des substances ci-avant. (I) (Dans la formule, tous les symboles sont tels que définis dans la description de l'invention.) Le composé de formule générale (I) est susceptible de se combiner à un récepteur S1P (plus particulièrement EDG-1, EDG-6, et/ou EDG-8). Il peut être employé dans le traitement prophylactique et/ou thérapeutique de réactions de rejet suite à une transplantation, de réaction de greffe contre l'hôte, de maladies auto-immunes, de maladies allergiques, de maladies neurodégénératives, etc.

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