Aminocarboxylic acids, amino alcohols, or the derivatives...

Details Aminocarboxylic acids, amino alcohols, or the derivatives... Aminocarboxylic acids, amino alcohols, or the derivatives...

A - Human Necessities

61

K

260/602, 260/492

A61K 31/24 (2006.01) A61K 31/135 (2006.01) A61K 31/195 (2006.01) C07D 295/18 (2006.01)

Patent

CA 1176267

Abstract of the Disclosure A compound represented by the following formula Image wherein R1 represents a hyfrogen atom, an acyl group or an alkoxycarbonlyl group; X1 represents an alkylene group having 3 to 6 carbon atoms, a 1,4-cyclohexylene group, or a 1,4-phenylene group, the alkylene group may be substituted by an alkyl group having 1 to 6 carbon atoms, and the 1,4-phenylene group may be substituted by 1 ot 2 substituted selected from halogen atoms and alkoxy groups having 1 to 6 carbon atoms; R2 represents a hydrogen atom or a hydroxyl group and R3 represents hydrogen atom, or R2 and R3 together may form an oxo group (=O), and when X1 is other than the 1,4-phenylene group, R2 represents a hydrogen atom and R3 represents a bond between the carbon atom of X1 which is adjacent to said carbon atom; X2 represents an alkylene group having 1 to 5 carbon atoms which may be substituted by an alkyl group having 1 to 6 carbon atoms or an amino group; and R4 represents the group -COOR5, -CH2OR6 or -CONR7R3 in which R5 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R6 represents a hydrogen atoms or and acyl group having 1 to 6 carbon atoms, and R7 and R3 are identical or different and represent a hydrogen atom ot an alkyl group having 1 to 6 carbon atoms or taken together may form a 5- or 6-membered ring; or an acid addition salts of said compound wherein R1 re- presents a hydrogen atom or X2 represents an alkylene group having an amino group, or a salts of said compound wherein R5 represents a hydrogen atom. The compound represented by the above formula or its pharmaceutically acceptable salt is useful as an anti- ulcer agent. The present invention also provides a process for producing the compound or its pharmaceutically acceptable salt, which comprises acylating a protected derivative at the amino group of a corresponding acid halide with a corres- ponding substituted benzene in the presence of a Lewis acid; or reducing a corresponding compound in the presence of an inert solvent under conditions which induce reduction of the carbonyl group of said corresponding compound without sub- stantially reducing the phenylene group of said corresponding compound; or dehydrating a corresponding compound.

382012

Affiliated with

Also associated with

Rating

Aminocarboxylic acids, amino alcohols, or the derivatives... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aminocarboxylic acids, amino alcohols, or the derivatives..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminocarboxylic acids, amino alcohols, or the derivatives... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1239627