Aminocyclitol antibiotics and processes therefor

Details Aminocyclitol antibiotics and processes therefor Aminocyclitol antibiotics and processes therefor

C - Chemistry, Metallurgy

12

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195/89

C12P 19/00 (2006.01) C07C 45/58 (2006.01) C07C 49/497 (2006.01) C07D 231/54 (2006.01) C07D 303/14 (2006.01) C07D 498/04 (2006.01) C07H 15/236 (2006.01)

Patent

CA 1061731

ABSTRACT OF THE DISCLOSURE Aminocyclitol analogs of gentamisin C1, C2 and C1a and the corresponding compounds acylated on the 1-, 3- and 2'-amino groups with an .omega.-amino-.alpha.-hydrowy-lower-alkanoyl group are prepared by culturing a nutrient medium containing carbo- hydrates, a source of assimilabe nitrogen, essential salts and an added cyclitol or aminocyclitol with mutants of Micromonospora purpurea and acylating the product with an ester of an .omega.-N- benzyloxycarbonyl) amino-.alpha.-hydroxy-lower-alkanoic acid followed by catalytic hydrogenolysis of the benzyloxycarbonyl group.

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