Aminocycloalkane compounds

Details Aminocycloalkane compounds Aminocycloalkane compounds

C - Chemistry, Metallurgy

07

C

C07C 237/20 (2006.01) A61K 31/165 (2006.01) A61K 31/275 (2006.01) A61K 31/277 (2006.01) A61K 31/34 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61P 1/04 (2006.01) A61P 11/00 (2006.01) A61P 13/10 (2006.01) A61P 25/00 (2006.01) C07C 255/42 (2006.01) C07D 207/09 (2006.01) C07D 213/38 (2006.01) C07D 233/61 (2006.01) C07D 277/28 (2006.01) C07D 295/14 (2006.01) C07D 307/52 (2006.01) C07D 307/79 (2006.01)

Patent

CA 2296329

Aminocycloalkane compounds represented by general formula (I) or pharmacologically acceptable salts thereof wherein Ar represents optionally substituted phenyl or thienyl; X represents cyano or carbamoyl; R1 and R2 each independently represents hydrogen, lower alkyl, etc. or R1 and R2 together with the nitrogen atom bonded thereto represent (II) (wherein R3 represents hydrogen, lower alkyl, etc.); and m is 2, 3, or 4. The compounds have a highly selective antagonistic action on a muscarine M3 receptor.

Composés d'aminocycloalcane, représentés par la formule générale (I), dans laquelle Ar représente phényle ou thiényle éventuellement substitué; X représente cyano ou carbamoyle; R¿1? et R¿2? représentent indépendamment hydrogène, alkyle inférieur, etc., ou bien R¿1? et R¿2?, avec l'atome d'azote qui leur est lié, représentent (II) (où R¿3? représente hydrogène, alkyle inférieur, etc.); et m est égal à 2, 3 ou 4; et leurs sels pharmaceutiquement acceptables. Ces composés ont une activité antagoniste hautement sélective vis-à-vis du récepteur muscarinique M¿3?.

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