C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61K 31/4162 (2006.01) A61K 31/4188 (2006.01) A61K 31/424 (2006.01) A61K 31/429 (2006.01) A61P 3/10 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2636757
The present invention is directed to novel substituted aminocyclohexanes of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
La présente invention concerne de nouveaux aminocyclohexanes substitués représentés par la formule (I) qui sont des inhibiteurs de l'enzyme dipeptidyl peptidase-IV et qui sont utiles dans le traitement ou la prévention des maladies dans lesquelles est impliquée la dipeptidyl peptidase-IV, maladies telles que le diabète et plus particulièrement le diabète de type 2. Cette invention porte également sur des compositions pharmaceutiques comprenant lesdits composés et sur l'utilisation de ces composés et de ces compositions dans la prévention ou le traitement des maladies dans lesquelles la dipeptidyl peptidase-IV est impliquée.
Biftu Tesfaye
Cox Jason
Feng Danqing
Mastracchio Anthony
Qian Xiaoxia
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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