C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/404 (2006.01) A61K 31/429 (2006.01) A61K 31/4743 (2006.01) A61K 31/4745 (2006.01) A61K 31/4985 (2006.01) A61P 3/06 (2006.01) A61P 3/10 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2570807
The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase- IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. Compounds of the invention include the compound of formula I (see formula I)
La présente invention est orientée vers des amino cyclohexanes substitués novateurs qui représentent des inhibiteurs de l'enzyme dipeptidyl peptidase-IV ("inhibiteurs DPP-IV") et qui sont utiles dans le traitement ou dans la prévention des maladies dans lesquelles est impliquée l'enzyme dipeptidyl peptidase-IV, telles que les diabètes et en particulier les diabètes de Type 2. L'invention est également orientée vers des compositions pharmaceutiques comprenant ces composés et vers l'utilisation de ces composés et compositions dans la prévention ou dans le traitement de telles maladies dans lesquelles est impliquée l'enzyme dipeptidyl peptidase-IV.
Biftu Tesfaye
Feng Danqing Dennis
Gao Ying-Duo
Singh Suresh
Weber Ann E.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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