C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 3/10 (2006.01) A61K 31/155 (2006.01)
Patent
CA 2607441
The present invention is directed to novel substituted aminocyclohexanes which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase- IV enzyme is involved.
La présente invention a trait à de nouveaux aminocyclohexanes substitués qui sont inhibiteurs de l'enzyme dipeptidyle peptidase-IV (inhibiteurs DPP-IV) et qui sont utiles dans le traitement ou la prévention de maladies dans lesquelles l'enzyme dipeptidyle peptidase-IV est impliquée, telles que le diabète et en particulier le diabète de type 2. L'invention a également trait à des compositions pharmaceutiques comportant ces composés et l'utilisation de ces composés et compositions dans la prévention ou le traitement de telles maladies dans lesquelles l'enzyme dipeptidyle peptidase-IV est impliquée.
Biftu Tesfaye
Cox Jason
Feng Danqing
Qian Xiaoxia
Weber Ann E.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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