Aminocyclopentanol acids and esters and their preparation...

Details Aminocyclopentanol acids and esters and their preparation... Aminocyclopentanol acids and esters and their preparation...

C - Chemistry, Metallurgy

07

D

260/247.1, 260/2

C07D 295/14 (2006.01) C07C 405/00 (2006.01) C07D 295/112 (2006.01) C07D 295/116 (2006.01) C07D 295/155 (2006.01) C07D 307/00 (2006.01) C07D 309/12 (2006.01) C07D 333/16 (2006.01) C07D 409/12 (2006.01)

Patent

CA 1191134

ABSTRACT Compounds are described of the formula Image in which R1 is H, C1-6 alkyl or C7-10 aralkyl; W is C1-7 alkylene; X is cis or trans -CH=CH- or -CH2CH12-; n is 1 or 2; Y is a saturated heterocyclic amino group having 5-8 ring members; R2 is (1) substituted or unsubstituted phenylalkyl, thienylalkyl or naphthylalkyl or (ii) substituted or unsubstituted cinnamyl; and their salts and solvates. These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and antiasthmatic agents.

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