A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 43/64 (2006.01) A61K 31/4985 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) C07D 241/36 (2006.01) C07D 253/08 (2006.01) C07D 471/00 (2006.01) C07D 487/00 (2006.01)
Patent
CA 2554387
Compounds of Formula I and Formula II (wherein A, E, j, k, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, X, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
L'invention concerne des composés représentés par la formule (I) et la formule (II) : (I, II) (dans lesquelles A, E, j, k, m, n, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, R?7¿, R?8¿, R?9¿, R?10¿, R?15¿, R?16¿, R?17¿, R?18¿, R?19¿, R?24¿, R?25¿, R?26¿, R?27¿, R?28¿, R?29¿, R?30¿, R?31¿, R?32¿, R?33¿, R?34¿, X, Y et Z correspondent aux définitions du descriptif) qui sont de modulateurs de l'activité du récepteur de chimiokine, et sont utiles pour la prévention et le traitement de certains troubles et maladies inflammatoires ou liés à l'immunorégulation, des maladies allergiques, d'états atopiques, notamment des rhinites allergiques, des dermatites, les dermatites, des conjonctivites et de l'asthme, ainsi que des pathologies auto-immunes tels que la polyarthrite rhumatoïde et l'athérosclérose. L'invention concerne également des compositions pharmaceutiques contenant ces composés, ainsi que l'utilisation de ces composés et de ces compositions pour la prévention ou le traitement des maladies dans lesquelles les récepteurs de chimiokines sont impliqués.
Butora Gabor
Guiadeen Deodialsingh
Kothandaraman Shankaran
Maccoss Malcolm
Mills Sander G.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Canada S.e.n.c.r.l.,s.r.l./llp
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