Aminodiol derivatives

Details Aminodiol derivatives Aminodiol derivatives

C - Chemistry, Metallurgy

07

D

C07D 317/28 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) A61K 31/44 (2006.01) C07D 317/72 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 417/06 (2006.01) C07F 9/655 (2006.01) C07H 7/04 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2045892

- 1 - Abstract of the disclosure HOE 90/F 200 Amninodiol derivatives The invention relates to compounds of the formula Image in which R1 and R2 are identical or different and are hydrogen or aralkyl, R3 is alkyl, cycloalkyl or cyclo- alkylalkyl, R4 and R5 are identical or different and are hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or a heterocyclic radical and R6 and R7 are identical or different and are hydrogen, alkyl, cyclo- alkyl, cycloalkylalkyl, aryl or arlkyl or R6 and R7, together with the carbon atom carrying them, are cyclo- alkyl. The novel compounds are prepared by a carbonyl olefination according to Wittig. They are intermediates for the preparation of pharmaceuticals, in particular of inhibitors of renin and HIV protease.

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