Aminoethylglycine containing polypeptides

Details Aminoethylglycine containing polypeptides Aminoethylglycine containing polypeptides

C - Chemistry, Metallurgy

07

K

530/7.04

C07K 14/655 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1113457

ABSTRACT Polypeptides of the formula Image I wherein A is L- or D-Trp, X is H-(Aeg)m-Cys- or H-(Aeg)m-Ala-Gly-Cys-, Y is -Cys-(Aeg)n-OH or X and Y taken together are a 2-aminoethyl- glycyl group in the ring position and m and n are 0, 1, 2, 3 or 4, provided that m + n are at least 1, the cyclic disulfide derivatives, protamine zinc and protamine aluminum complexes and pharmaceutically acceptable acid addition salts thereof, having valuable pharmacological properties, and methods for the preparation thereof using conventional liquid or solid phase syntheses.

312934

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