Aminoethylthiazole and aminoethyloxazole derivatives

Details Aminoethylthiazole and aminoethyloxazole derivatives Aminoethylthiazole and aminoethyloxazole derivatives

C - Chemistry, Metallurgy

07

D

167/233, 260/302

C07D 277/40 (2006.01) A61K 31/425 (2006.01) C07D 263/48 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2010409

ABSTRACT The invention relates to aminoethylthiazole and aminoethyloxazole derivatives with the general formula I Image I wherein X is O or S; ALK is a hydrocarbyl (C2-C6) group; R1 is a substituted or unsubstituted aryl qroup; R2 is a hydrogen, a hydrocarbyl (C1-C6) group or an aralkyl (C7-C13) group; R3 is a substituted or unsubstituted amino group; or their pharmaceutically acceptable acid addition salts. These new compounds are dopamine agonists with selectivity for pre-synaptic dopamine receptors and, as such, are useful as anti-psychotics in the treatment of schizophrenia. The compounds are also useful in the treatment of hypertension, Parkinsonism and for the conditions of hyperprolactineamia, e.g. galactorrhea, menstrual disorders and amenorrhea.

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