C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/30 (2006.01) A61K 31/35 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2405747
The invention provides an aminoflavone having formula (I), wherein each of R1 and R2 is H, COCH2-R7, wherein R7 is amino, alkylamino, dialkylamino, or alkyl- or dialkylaminoalkyl, or an .alpha.-amino acid residue, provided that at least one of R1 or R2 is other than H, and R3 is H, branched or straight-chain alkyl, hydroxyalkyl, alkanoyloxyalkyl, alkanoyloxy, alkoxy, or alkoxyalkyl, or pharmaceutically acceptable salts thereof. The present invention also provides a pharmaceutical composition comprising an aminoflavone as described above, and a method of inhibiting the growth of a tumor in a host by administering a tumor growth-inhibiting amount of an aminoflavone compound having the formula as described above.
L'invention concerne une amino-flavone de la formule suivante, dans laquelle R?1¿ et R?2¿ représentent chacun H, COCH¿2?-R?7¿, R?7¿ étant amino, alkylamino, dialkylamino, ou alkyle- ou dialkylaminoalkyle, ou un résidu acide .alpha.-acide aminé, pour autant qu'au moins R?1¿ ou R?2¿ soit différent de H, et R?3¿ représente H, alkyle ramifié ou à chaîne droite, hydroxyalkyle, alcanoyloxyalkyle, alcanoyloxy, alcoxy, ou alcoxyalkyle, ou des sels de ceux-ci pharmaceutiquement acceptables. L'invention concerne également une composition pharmaceutique comprenant une amino-flavone, telle que décrite ci-dessus, et un procédé permettant d'inhiber chez un hôte la croissance d'une tumeur par administration d'une dose, suffisante pour inhiber la croissance d'une tumeur, d'un composé d'amino-flavone de la formule décrite ci-dessus.
Akama Tsutomu
Snader Kenneth M.
Vishnuvajjala B. Rao
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Kyowa Hakko Kogyo Co. Ltd.
R. William Wray & Associates
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