Aminoglycoside antibiotics for use as vap-1/ssao inhibitors

Details Aminoglycoside antibiotics for use as vap-1/ssao inhibitors Aminoglycoside antibiotics for use as vap-1/ssao inhibitors

A - Human Necessities

61

K

A61K 31/702 (2006.01) A61K 31/7056 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 19/04 (2006.01) A61P 25/02 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2545324

The present invention concerns the use of a compound comprising one or more sugar moieties, which optionally are aminosubstitutes, and possibly other moieties, wherein said compound is a molecule comprising at least two aminosubstituents, said aminosubstituents being primary, secondary or tertiary amino groups, wherein said aminosubstituents are either attached to one single sugar moiety or attached to several sugar moieties or other moieties of the molecule, or to chains connecting two moieties or to chains being substituents to the molecule, for the manufacture of a pharmaceutical preparation useful as an agent capable of influencing an amine oxidase enzyme activity, more particularly inhibiting VAP-1/SSAO activity. The preferred compounds are aminoglycoside antibiotics, e.g., streptomycin, netilmicin, geneticin, gentamicin, puromycin, tobramycin and amikacin. The preferred conditions to be treated are inflammatory diseases or conditions, diseases related to carbohydrate metabolism, diseases related to aberrations in adipocyte differentiation or function or smooth muscle cell function, and vascular diseases.

L'invention porte sur l'utilisation d'un composé qui comprend un ou plusieurs fragments sucre, qui sont facultativement des substituts amino, et éventuellement d'autres fragments, ledit composé étant une molécule qui comprend au moins deux substituants amino, lesdits substituants amino étant des groupes amino primaires, secondaires ou tertiaires, lesdits substituants amino étant soit attachés à un unique fragment sucre ou attachés à plusieurs fragments sucre ou autres fragments de la molécule, ou à des chaînes reliant deux fragments ou à des chaînes qui sont des substituants de la molécule, dans la fabrication d'une préparation pharmaceutique utilisée comme agent capable d'influencer l'activité d'une enzyme amine oxydase, en particulier d'inhiber l'activité de la VAP-1/SSAO. Les composés préférés sont des antibiotiques aminoglycosides, c'est-à-dire, la streptomycine, la netilmicine, la généticine, la gentamicine, la puromycine, la tobramycine et l'amikacine.Les états préférés à traiter sont les maladies ou états inflammatoires, les maladies liées au métabolisme des hydrates de carbone, les maladies liées aux aberrations de la différenciation ou de la fonction des adipocytes ou de la fonction des cellules des muscles lisses, et les maladies vasculaires.

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