C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 281/16 (2006.01) A61K 31/195 (2006.01) A61K 31/198 (2006.01) A61K 31/215 (2006.01) C07C 281/18 (2006.01)
Patent
CA 2202265
The present invention provides novel compounds of the formulae (I): AG-(CH2)n- CO2R1 and (II) or pharmacologically acceptable salts thereof, wherein AG is: a) N-aminoguanidine, b) N,N'-diaminoguanidine, or c) N,N',N"- triaminoguanidine; and n, R1 and R2 have the meanings given in the description as well as a new use for the compounds of formula (III) wherein R3 has the meanings given in the description for the treatment of non-insulin dependent diabetes mellitus (NIDDM).
On décrit de nouveaux composés des formules (I): AG-(CH¿2?)¿n?-CO¿2?R?1¿ et (II) ou leurs sels pharmacologiquement acceptables, où AG représente: a) N-aminoguanidine, b)N,N'-diaminoguanidine, ou c) N,N',N"-triaminoguanidine; et où n, R?1¿ et R?2¿ correspondent aux définitions de la description. On décrit aussi de nouvelles utilisations de composés de formule (III) où R?3¿ correspond aux définitions de la description. Ces composés servent pour le traitement du diabète sucré non insulinodépendant.
Larsen Scott D.
May Paul D.
Meglasson Martin D.
Schostarez Heinrich J.
Tanis Steven P.
Biovitrum Ab
Macrae & Co.
Pharmacia & Upjohn Company Llc
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