Aminoguanidine derivatives and a process for the preparation...

Details Aminoguanidine derivatives and a process for the preparation... Aminoguanidine derivatives and a process for the preparation...

C - Chemistry, Metallurgy

07

D

167/208, 167/264

C07D 295/20 (2006.01) C07D 211/34 (2006.01) C07D 265/30 (2006.01) C07D 295/215 (2006.01)

Patent

CA 1237129

A B S T R A C T The invention relates to new aminoguanidine derivatives of the general formula (I), Image wherein R1, R2 and R3 each represent hydrogen or halogen atom, C1-4 alkyl, nitro, trifluoromethyl or C1-4 alkoxy group, R4 and R5 represent a C1-4 alkyl group, furthermore NR4R5 may form a 5 to 7 membered saturated heterocyclic group containing either one or two nitrogen atoms or a nitrogen and an oxygen atom and being optionally substituted by one or two methyl, hydroxymethyl or hydroxyethyl groups, R6 and R7 each represent a hydrogen atom, normal or branched C1-4 alkyl or C2-4 alkenyl group, and to their pharmaceutically acceptable acid addition salts as well as to a process for the preparation thereof. - 2 - The new compounds of the invention possess valuable antiarrhythmic activity and are devoid of the undesired circulatory side effects of the known anti- arrhythmic compounds.

469862

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