Aminoguanidinehydrazone derivative, production and use thereof

Details Aminoguanidinehydrazone derivative, production and use thereof Aminoguanidinehydrazone derivative, production and use thereof

C - Chemistry, Metallurgy

07

D

C07D 209/08 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 31/47 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) C07D 209/06 (2006.01) C07D 209/88 (2006.01) C07D 215/38 (2006.01) C07D 215/60 (2006.01) C07D 221/04 (2006.01) C07D 231/56 (2006.01) C07D 237/28 (2006.01) C07D 239/74 (2006.01) C07D 261/20 (2006.01) C07D 307/79 (2006.01) C07D 307/84 (2006.01) C07D 333/36 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04

Patent

CA 2316944

Compounds represented by general formula (I) or salts thereof having preventive and therapeutic effects on ischemic heart diseases, etc., and being useful as preventives/remedies for ischemic heart diseases such as heart infarction and arrhythmia. In formula (I), A represents optionally substituted 5- or 6-membered heteroaryl; B represents an optionally substituted 5- or 6- membered aromatic homocycle or heterocycle; R1 represents hydrogen, hydroxy or lower alkyl; and n is 0 or 1.

L'invention concerne des composés représentés par la formule générale (I) ci-après ou des sels de ces composés, lesquels composés ont des effets préventifs et thérapeutiques sur les cardiopathies ischémiques, etc. et sont utilisés comme agents prophylactiques/remèdes pour les cardiopathies ischémiques telles que l'infarctus du myocarde et l'arhythmie. Dans la formule (I), A représente un hétéroaryle à 5 ou 6 éléments éventuellement substitué; B représente un homocycle ou un hétérocycle à 5 ou 6 éléments éventuellement substitué; R?1¿ représente hydrogène, un hydroxy ou un alkyle inférieur; et n est égal à 0 ou 1.

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