Aminoguanidines

Details Aminoguanidines Aminoguanidines

C - Chemistry, Metallurgy

07

D

C07D 209/18 (2006.01) A61K 31/33 (2006.01) A61K 31/675 (2006.01) A61K 31/695 (2006.01) C07D 209/14 (2006.01) C07D 333/58 (2006.01) C07D 333/60 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07F 7/08 (2006.01) C07F 7/10 (2006.01) C07F 9/572 (2006.01)

Patent

CA 2063671

Compounds of formula A-X--Y-NH-B wherein A is derived from optionally substituted benzothiophene, indole, 4-aza-and 7-aza-benzothiophene or-indole, A bearing in position 5 hydrogen, halogen, optionally substituted alkyl, hydroxy, nitro, amino, alkylamino, acylamino, alcoxycarbonyl, sulfamoyl, cyano, trimethylsilyl, carboxy, carbamoyl, phosphate, oxycarbamoyl, heterocyclic radical or ether or ester group, X--Y is -CR8=N- or CH(R8)-NH- wherein R8 is -H or alkyl and attached at position 3 of A, and B is a heterocyclic radical or a residue Image wherein R10 is H, optionally substituted alkyl, cycloalkyl, aryl, adamantyl, acyl or carbamoyl and X2 is alkylthio or NR3R10 wherein R3 is H or alkyl or R3 and R10 together with the nitrogen atom to which they are attached form a heterocyclic radical, in free form or in salt form, have pharmacological activity, e.g. for treating gastrointestinal disorders.

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