C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/101.5
C07D 501/59 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/20 (2006.01) C07D 501/22 (2006.01)
Patent
CA 1178270
4-13033/+ Aminohydroxyphenyl compounds, processes for their manu- facture, pharmaceutical preparations containing these compounds, and the use of these compounds. Abstract Novel 7.beta.-[D-2-amino-2-(aminohydroxyphenyl)- acetylamino]-ceph-3-em-4-carboxylic acid compounds of the formula Image in which R represents hydrogen or an acyl group, R0 represents hydrogen or lower alkyl, R1 represents hydrogen or a group of the partial formula (R)(Ro)N-, R2 represents carboxyl or protected carboxyl, and R3 represents hydrogen, halogen having an atomic number of up to 35 or lower alkoxy, are manufactured. Intermediates are also included. The novel compounds have valuable antibiotic properties and are effective against both gram-positive and gram-negative micro-organisms and have a low toxi- city. They may therefore be used for the treatment of corresponding infections.
384521
Scartazzini Riccardo
Wiederkehr Rene
Fetherstonhaugh & Co.
Novartis Ag
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