Aminoimidazoquinoline derivatives

Details Aminoimidazoquinoline derivatives Aminoimidazoquinoline derivatives

C - Chemistry, Metallurgy

07

D

167/211, 260/246

C07D 471/04 (2006.01) A61K 31/47 (2006.01) A61K 31/535 (2006.01)

Patent

CA 1309095

ABSTRACT Novel series of 2,3-dihydro-2-oxo-1H-imidazo- [4,5-b]quinolinyl amine derivatives of Formula Image wherein R1 is hydrogen, lower alkyl; R2 is hydrogen, lower alkyl, lower alkoxy, halogen; R3 is hydrogen, lower alkyl, R4 is hydrogen, lower alkyl, alkanoyl, phenylalkanoyl wherein phenyl is optionally substituted with halogen, lower alkyl, or lower alkoxy; R3 and R4 are joined together to form morpholinyl, piperidinyl or pyrrolidinyl optionally substituted with -CO2R5 or -?NR5R6 wherein R5 is wherein R5 is hydrogen or lower alkyl, and R6 is hydrogen, lower alkyl, cycloalkyl; 4-R7-piperazinyl wherein R7 is -CO2R8 wherein R8 is lower alkyl, phenyl optionally substituted with up to 2 halogen, lower alkyl or lower alkoxy; phenylalkanoyl of 7 to 10 carbon wherein phenyl is unsubstituted or independently substituted with up to 2 halogen, lower alkyl, lower alkoxy. The compounds are cyclic AMP phosphodiesterase inhibitors and are particularly useful as inhibitors of blood platelet aggregation and/or as cardiotonic agents.

541538

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