Aminoindazole derivatives active as kinase inhibitors,...

Details Aminoindazole derivatives active as kinase inhibitors,... Aminoindazole derivatives active as kinase inhibitors,...

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/416 (2006.01) A61P 35/00 (2006.01) C07D 231/56 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2460145

Compounds of formula (I): (see formula I) or a pharmaceutically acceptable salt thereof, wherein R is -NHR', -NR'R", -NHCOR', -NHCONHR', -NHCONR'R", -NHSO2R' or -NHCOOR', wherein R' and R" are, each independently, an optionally substituted straight or branched C1-C6 alkyl, C2-C6 alkenyl or alkynyl, C3-C6 cycloalkyl or cycloalkyl C1-C6 alkyl, aryl, aryl C1-C6 alkyl, 5 or 6 membered heterocyclyl or heterocyclyl C1-C6 alkyl with from 1 to 3 nitrogen, oxygen or sulfur heteroatoms; or R is a phthalimido group of formula (II) below (see formula II) any (R1O)m, if present, is in position 5 or 6 of the indazole ring and R1 is defined as R' and R" are defined; and m is 0 or 1; together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

Cette invention a trait à des composés, en l'occurrence des dérivés de 3-aminoindazole ou leurs sels acceptables du point de vue pharmaceutique, ainsi qu'à des compositions pharmaceutiques les contenant. Ces composés ou ces compositions se révèlent des plus utiles pour traiter des états pathologiques provoqués par l'activité de protéine kinase modifiée ou associés à celle-ci, tels que des cancers, des troubles de prolifération cellulaire, la maladie d'Alzheimer, des infections virales, des maladies auto-immunes et des troubles neurodégénératifs.

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