Aminoindazole derivatives active as kinase inhibitors,...

Details Aminoindazole derivatives active as kinase inhibitors,... Aminoindazole derivatives active as kinase inhibitors,...

C - Chemistry, Metallurgy

07

D

C07D 231/56 (2006.01) A61K 31/416 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2486101

Compounds which are indazole derivatives and pharmaceutically acceptable salts thereof together with pharmaceutical compositions comprising them, as well as combinatorial libraries of indazole derivatives, as set forth in the specification, are disclosed; these compounds or compositions may be useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

Cette invention concerne des composés qui sont des dérivés d'indazole et des sels de ces composés acceptables au plan pharmaceutique, des compositions pharmaceutiques les renfermant ainsi que des banques combinatoires de dérivés d'indazole, comme définis dans le descriptif. Ces composés ou compositions peuvent être utiles pour le traitement de maladies provoquées par/ ou associées à une altération de l'activité protéine kinase telles que cancer, troubles de la prolifération cellulaire, maladie d'Alzheimer, infections virales, maladies auto-immunes et maladies neurodégéneratives.

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