Aminoisoxazole derivatives active as kinase inhibitors

Details Aminoisoxazole derivatives active as kinase inhibitors Aminoisoxazole derivatives active as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/4439 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2455631

Compounds (I) which are aminoisoxazole derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

Cette invention, qui a trait à des composés correspondant à la formule (I) et qui sont des dérivés d'aminoisoxazole ou leurs sels acceptables du point de vue pharmaceutique, concerne également des compositions pharmaceutiques renfermant ces composés. Ces composés ainsi que ces compositions se révèlent des plus utiles dans le traitement d'états pathologiques provoqués par une altération de l'activité de la protéine kinase ou bien associés à cette altération, notamment le cancer, des troubles de la prolifération cellulaire, la maladie d'Alzheimer, des infections virales, des maladies auto-immunes et des troubles neurodégénératifs.

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