Aminoketone asymmetric reductase and nucleic acid thereof

Details Aminoketone asymmetric reductase and nucleic acid thereof Aminoketone asymmetric reductase and nucleic acid thereof

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12N 9/04 (2006.01) C12N 11/00 (2006.01) C12N 15/31 (2006.01) C12N 15/63 (2006.01) C12P 7/02 (2006.01) C12P 13/00 (2006.01) C12P 21/02 (2006.01) C12P 41/00 (2006.01)

Patent

CA 2440025

A protein, which is an aminoketone asymmetric reductase, having an effect of producing d-pseudoephedrine by acting on 1-2-methylaminopropiophenone, and having the following physiochemical properties: substrate: 1-2-methylaminopropiophenone optimum pH: pH 8.1 optimum temperature: 55°C coenzyme: NADP molecular weight: about 28500 Da homotetramer and a nucleic acid coding the protein.

L'invention porte sur une protéine, à savoir une aminocétone réductase asymétrique, agissant sur un 1-2-méthylaminopropiophénone afin d'obtenir une d-pseudoéphédrine et possédant les propriétés physicochimiques suivantes; ainsi que l'acide nucléique codant cette protéine: substrat: 1-2-méthylaminopropiophénone; valeur pH optimale: 8,1; température optimale: 55 °C; coenzyme: NADP; et poids moléculaire: homotétramère d'environ 28 500 Da.

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