Aminoketone derivatives

Details Aminoketone derivatives Aminoketone derivatives

C - Chemistry, Metallurgy

07

D

C07D 307/38 (2006.01) A61K 31/33 (2006.01) C07D 213/24 (2006.01) C07D 213/32 (2006.01) C07D 213/38 (2006.01) C07D 215/14 (2006.01) C07D 263/20 (2006.01) C07D 263/24 (2006.01) C07D 277/22 (2006.01) C07D 277/26 (2006.01) C07D 307/42 (2006.01) C07D 307/46 (2006.01) C07D 307/85 (2006.01) C07D 309/00 (2006.01) C07D 333/06 (2006.01) C07D 333/16 (2006.01) C07D 333/18 (2006.01) C07D 333/22 (2006.01) C07D 333/54 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2111930

118 ABSTRACT OF THE DISCLOSURE Aminoketone derivatives according to the present invention strongly inhibits thiol protease such as calpain, papain, cathepsin B, cathepsin H, cathepsin L or the like and has excellent properties concerning absorbance on oral administration, tissue distribution and cell membrane permeability. The aminoketone derivatives can thus be used as therapeutic agents for treating muscular dystrophy, cataract, cardiac infarction, stroke, Alzheimer's disease, amyotrophy, osteoporosis and hypercalcemia and so on. It may also be used as therapeutic agents for preventing metastasis of cancer. In addition, the present derivatives are also applicable as the intermediates upon preparation of ketone derivatives, which has the inhibitory activity against thiol protease.

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