Aminomacrolides and derivatives having immuno-suppressive...

Details Aminomacrolides and derivatives having immuno-suppressive... Aminomacrolides and derivatives having immuno-suppressive...

C - Chemistry, Metallurgy

07

H

167/202, 260/228

C07H 17/00 (2006.01) A61K 31/70 (2006.01) C07H 19/01 (2006.01)

Patent

CA 2029860

21/JET 18044IA TITLE OF THE INVENTION AMINOMACROLIDES AND DERIVATIVES HAVING IMMUNOSUPPRESSIVE ACTIVITY ABSTRACT OF THE DISCLOSURE Aminomacrolides of the general structural Formula I: Image I 21/JET - i - 18044IA have been prepared from suitable precursors by incorporation of a nitrogen substituent at C-3" and/or C-4" of the cyclohexyl ring. These macrolide immunosuppressants are useful in a mammalian host for the treatment of autoimmune diseases, infectious diseases and/or the prevention of rejection of foreign organ transplants. In addition, these macrolide immunosuppressants are useful in the topical treatment of inflammatory and hyperproliferative skin diseases and cutaneous manifestations of immunologically-mediated illnesses.

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