C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/18 (2006.01) A61K 31/439 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2679885
The invention relates to compounds that are substituted aminomethyl azaadamantane derivatives of formula ( I ), compositions comprising such compounds, and the use of such compounds and compositions for treating or preventing conditions, disorders or deficits modulated by an .alpha.7 nicotinic acetylcholine receptor, an .alpha.4.beta.2 nicotinic aetylcholine receptor or both .alpha..7 and .alpha.4.beta.2 nicotinic acetylcholine receptor wherein the condition, disorder or deficit is selected from the group consisting of a memory disorder, cognitive disorder, neurodegeneration, and ne.upsilon.rodevelopmental disorder.
L'invention concerne des composés dérivés d'aminométhyl azaadamantane substitués de formule (I), des compositions comprenant de tels composés, et l'utilisation de tels composés et compositions pour traiter ou prévenir des affections, troubles ou déficits modulés par un récepteur d'acétylcholine nicotinique a7, un récepteur d'acétylcholine nicotinique a4b2 ou des récepteurs d'acétylcholine nicotinique à la fois a7 et a4b2, l'affection, le trouble, ou le déficit étant choisi dans le groupe constitue par les troubles de la mémoire, les troubles cognitif, les neurodégénérescences, et les troubles neurodévelopementaux.
Bunnelle William H.
Scanio Marc J.c.
Shi Lei
Abbott Laboratories
Torys Llp
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