C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/06 (2006.01) A61K 31/4245 (2006.01) A61K 31/433 (2006.01) A61K 31/496 (2006.01) C07D 271/10 (2006.01) C07D 417/06 (2006.01)
Patent
CA 2594943
The present invention is directed to aminomethyl compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
La présente invention concerne des composés d'aminométhyle qui sont des inhibiteurs de l'enzyme .beta.-secrétase et qui sont utilisés dans le traitement de maladies, dans lesquelles est impliquée ladite enzyme .beta.-secrétase, telles que la maladie d'Alzheimer. Cette invention a aussi pour objet des compositions pharmaceutiques renfermant ces composés et l'utilisation desdits composés et compositions dans le traitement de maladies, dans lesquelles est impliquée l'enzyme .beta.-secrétase.
Coburn Craig A.
Nantermet Philippe G.
Rajapakse Hemaka A.
Selnick Harold G.
Stauffer Shaun R.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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