C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/304, 260/311
C07D 263/28 (2006.01) C07D 263/20 (2006.01) C07D 263/24 (2006.01) C07D 413/12 (2006.01)
Patent
CA 1275652
TITLE AMINOMETHYL OXOOXAZOLIDINYL BENZENE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS Abstract of the Disclosure Intermediates useful in the manufacture of aminomethyl oxooxazolidinyl benzene derivatives are disclosed. The intermediates have the formula: Image wherein A is either H or COR13 and (i) when A is H then, for the Q, and mixtures of the d and ? stereoisomers of the compound, R12 is H, C1-C10 alkyl or C3-C8 cycloalkyl; and when (ii) A is COR13 then, for the ?, and mixtures of the d and ? stereoisomers of the compound, R12 is H. C1-C10 alkyl or C3-C8 cycloaklyl; R13 is H; C1-C4 alkyl optionally substituted with one or more halogen atoms; C2-C4 alkenyl; C3-C4 cycloalkyl; phenyl; -CH2OR15; -CH(OR16)OR17; -CH2S(O)vR14; Image ; -OR18; -SR14; the aminoalkyl groups derived from .alpha.-amino acids selected from the group consisting of glycine, L-alanine, L-cysteine, L-proline, and D-alanine; 2. -NR19R20; or C(NH2)R21R22; R14 is C1-C4 alkyl, optionally substituted with one or more halogen atoms; R15 is H or C1-C4 alkyl, optionally substituted with one or more halogen atoms; R16 is R17 are independently C1-C4 alkyl or, taken together, are -(CH2)m-; R18 is C1-C4 alkyl or C7-C11 aralkyl R19 and R20 are independently H or C1-C4 alkyl, R21 and R22 are independently H, C1-C4 alkyl, C3-C6 cycloalkyl phenyl or, taken together, are -(CH2)s-; m is 2 or 3; v is 0, 1 or 2. s is 2, 3, 4 or 5.
580778
E.i. Du Pont de Nemours And Company
Sim & Mcburney
The Du Pont Merck Pharmaceutical Company
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