Aminomethyloxooxazolidinyl ethenylbenzene derivatives useful...

Details Aminomethyloxooxazolidinyl ethenylbenzene derivatives useful... Aminomethyloxooxazolidinyl ethenylbenzene derivatives useful...

C - Chemistry, Metallurgy

07

D

167/180, 260/304

C07D 263/20 (2006.01) A61K 31/42 (2006.01) C07D 413/10 (2006.01)

Patent

CA 1317594

BP-6330 Title AMINOMETHYLOXOOXAZOLIDINYL ETHENYLBENZENE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS Abstract of the Disclosure The following has useful antibacterial activity: a compound having the formula: Image (I) wherein for the ? isomer or racemic mixtures containing it B is NH2, Image , Image , or N3 u is 1 or 2: R4 is H, alkyl of 1-10 carbon atoms, or cycloalkyl of 3-8 carbon atoms; R5 is H, alkyl of 1-4 carbon atoms optionally substituted with one or more halogen atoms, alkenyl of 2-4 carbon atoms cycloalkyl of 3-4 carbon atoms, phenyl: OR6, or CH2OR4: R6 is alkyl of 1-4 carbon atoms optionally substituted with one or more halogen atoms R7 is H, CH3, C2H5, F or OH; R1 independently is H, CF3 alkyl of 1-3 carbon atoms optionally substituted with one halogen, phenyl, or phenyl optionally substituted with one or more halogen atoms, or taken together with R2 forms a 5-, 6-, or 7-membered ring of the formula: Image or -(CH2)p- when R3 is an electron-withdrawing group: R2 and R3 independently are an electron-withdrawing group, H, CF3, alkyl of 1-3 carbon atoms optionally substituted with one halogen, or phenyl, provided at least one of R2 or R3 is an electron-withdrawing group, or R2and R3 taken together form a 5, 6 or 7-membered ring of the formula: Image m is 1, 2 or 3; u is 2, 3 or 4; p is 3, 4 or 5; and X is CH2, O, S, or NR where R is H or alkyl of 1-5 carbon atoms; or a pharmaceutically suitable salt thereof.

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