Aminonaphthacene derivatives and process for preparation...

A - Human Necessities – 61 – K

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260/208

A61K 31/135 (2006.01)

Patent

CA 1197505

- 1 - Abstract: The invention provides aminonaphthacene derivatives of the formula: Image (I) wherein R1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R2 is a hydrogen atom or a hydroxyl group, R3 is a hydrogen atom or a lower alkanoyl group and R4 and R5, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a lower hydroxyalkyl group or a group of the formula. Image (II) wherein A is an alkylene group which may have one or more lower alkyl substituent(s) and R6 and R7 which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a lower hydroxyalkyl group or a lower aminoalkyl group; and acid addition salts thereof. These compounds are useful as anti-tumor agents.

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