Aminonaphthacene derivatives and their production

Details Aminonaphthacene derivatives and their production Aminonaphthacene derivatives and their production

C - Chemistry, Metallurgy

07

D

260/208

C07D 317/28 (2006.01) C07D 295/10 (2006.01) C07C 97/18 (1980.01)

Patent

CA 1184902

Abstract: Aminonaphthacene derivatives of the formula: Image (I) wherein R1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R is a hydrogen atom or a hydroxyl group, R3 and R4 are each a lower alkoxy group or, when taken together, represent an ethylenedioxy group or an oxo group and R5 and R6 are each a hydrogen atom, a lower alkyl group or a group of the formula: -A-Q (A) (in which A is an alkylene group optionally bearing at least one lower alkyl and Q is a hydrogen atom, a hydroxyl group, a lower alkoxy group or a group of the formula: Image (B) wherein R7 and R8 are each a hydrogen atom, a lower alkyl group, a benzyl group, a hydroxy(lower)alkyl group or an amino(lower)alkyl group or, when taken together with the adjacent nitrogen atom to which they are attached, represent a 5 to 7-membered nitrogen- containing ring optionally having an additional nitrogen or oxygen atom in the ring and optionally bearing any substituent on the ring or, when taken together with the adjacent nitrogen atom to which they are attached, represent a 5 to 7-membered nitrogen-containing ring optionally having an additional nitrogen or oxygen atom in the ring and optionally bearing any substituent on the ring, and their acid addition salts, which are useful as anti-tumor agents.

408400

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