Aminooxime derivatives of 2- and/or 4-substituted...

Details Aminooxime derivatives of 2- and/or 4-substituted... Aminooxime derivatives of 2- and/or 4-substituted...

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/565 (2006.01) A61K 31/58 (2006.01) A61P 9/04 (2006.01) A61P 9/06 (2006.01) A61P 9/12 (2006.01) C07J 43/00 (2006.01)

Patent

CA 2702111

New aminooxime derivatives at position 3 of 2-and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described,where the radicals have the meanings described in detail in the application.

L'invention concerne de nouveaux dérivés d'aminooxime en position 3 d'androstanes et androstènes 2- et/ou 4-substitués, des procédés pour leur préparation et des compositions pharmaceutiques les contentant pour le traitement de troubles cardiovasculaires, tels qu'une insuffisance cardiaque et une hypertension. En particulier, l'invention concerne des composés représentés par la formule générale (I), les radicaux ayant les significations décrites en détail dans la description.

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