C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/10 (2006.01) C07H 19/16 (2006.01) C07H 19/20 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2339408
Nucleosidic monomers and oligomeric compounds prepared therefrom are provided which have increased nuclease resistance, substituent groups (such as 2'- aminooxy groups) for increasing binding affinity to complementary strand, and regions of 2'-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H. Such oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics.
On décrit des monomères nucléosidiques et des composés oligomères préparés à partir de ces derniers qui présentent une meilleure résistance aux nucléases, possèdent des groupes substituants (tels que des groupes 2'-aminooxy) qui améliorent l'affinité de liaison au brin complémentaire, et des régions de nucléotides 2'-désoxy-érythro-pentofuranosyle qui activent RNase H. Ces composés oligomères sont utiles à des fins de diagnostic et de recherche, pour moduler l'expression d'une protéine dans des organismes, et pour diagnostiquer, détecter et traiter d'autres états pathologiques susceptibles d'être traitées par les oligonucléotides.
Cook Phillip Dan
Kawasaki Andrew M.
Manoharan Muthiah
Prakash Thazha P.
Isis Pharmaceuticals Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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