C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01)
Patent
CA 2278715
Nucleotide compositions containing aminooxy moieties are provided. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the nucleoside moieties of the oligonucleotide is modified to include an aminooxy moiety.
L'invention porte sur des compositions nucléotides contenant des fractions aminooxy. Selon des réalisations préférées, des oligonucléotides et leurs analogues peuvent spécifiquement s'hybrider avec une séquence sélectionnée d'ARN ou d'ADN dans laquelle au moins une des fractions nucléoside de l'oligonucléotide est modifiée de façon à comprendre une fraction aminooxy.
Cook Phillip Dan
Kawasaki Andrew Mamoru
Manoharan Muthiah
Isis Pharmaceuticals Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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