Aminopeptidase inhibitor

Details Aminopeptidase inhibitor Aminopeptidase inhibitor

C - Chemistry, Metallurgy

12

N

260/468, 260/525

C12N 9/99 (2006.01) C07C 101/34 (1980.01)

Patent

CA 1142868

ABSTRACT OF THE DISCLOSURE A reversible inhibitor of an aminopeptidase specific for N-terminal aspartylpeptides having the chemical formula: Image where, in aqueous solution at physiological pH, Z is an anionic group Y is a cationic group, n is 1 or 2, and X is either hydrogen or halogen is described. Preferably, the inhibitor is: Image where X is Cl or Br and n is 1 or 2. The asterisk denotes an asymmetric center in the L-configuration.

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