C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 295/135 (2006.01) A61K 31/135 (2006.01) A61K 31/44 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07C 215/80 (2006.01) C07C 217/76 (2006.01) C07D 211/22 (2006.01) C07D 211/46 (2006.01) C07D 213/38 (2006.01) C07D 213/64 (2006.01) C07D 213/74 (2006.01) C07D 243/08 (2006.01) C07D 279/24 (2006.01) C07D 279/26 (2006.01) C07D 295/13 (2006.01) C07D 401/02 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2065526
ABSTRACT OF THE DISCLOSURE Aminophenol derivatives of the following formula (I) Image (I) wherein X is hydrogen atom, lower alkyl or a protecting group for phenolic hydroxy, Y is hydrogen atom or lower alkyl, Z is hydrogen atom, lower alkyl, halogen atom or trifluoromethyl, A is hydrogen atom or lower alkyl, t is an integer of 1 to 5, l and m are respectively an integer of 2 to 4, E and W are nitrogen atoms, F is a direct bond or oxygen atom, P and Q are each hydrogen atom, halogen atom, lower alkyl or lower alkoxy, and R8 is hydrogen atom, hydroxy or a hydroxy-protecting group, and their pharmcologically acceptable salts. Since the aminophenol derivatives (I) of the present invention have excellent antioxidative action and antiinflammatory and antiallergic action in mammalian animals including human, they are extremely useful as pharmaceuticals such as an antiinflammatory or an antiallergic.
Akaboshi Fumihiko
Fukaya Chikara
Goto Tomokazu
Kajii Masahiko
Kondoh Takao
Fetherstonhaugh & Co.
The Green Cross Corporation
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