Aminophenoxyacetic acid derivatives and pharmaceutical...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 211/58 (2006.01) A61K 31/4468 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/5377 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) C07D 211/96 (2006.01) C07D 401/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2315050

There is provided an aminophenoxyacetic acid derivative of formula (I), wherein: R1, R2, R3 and R4 are independent from each other, alkoxy group, alkyl group or aryl group, etc.; E1 and E2 are oxygen atom, sulfur atom, etc.; n is 0 to 5; X and Y are alkylene group, cycloalkylen group, or alkenylen group; Q is phenyl group which may be substituted or benzoyl group, etc.; or a pharmaceutically acceptable salt thereof. These compounds have neuroprotective effects by inducing calbindin D28kd, one of Ca2+ -binding proteins.

L'invention concerne un dérivé d'acide aminophénoxyacétique représenté par la formule (I), ou un sel de celui-ci pharmaceutiquement acceptable. Dans cette formule, R<1>, R<2>, R<3> et R<4> représentent, indépendamment l'un de l'autre, un groupe alcoxy, un groupe alkyle ou un groupe aryle etc.; E<1> et E<2> représentent un atome d'oxygène, un atome de soufre, etc.; n est compris entre 0 et 5; X et Y représentent un groupe alkylène, un groupe cycloalkylène, ou un groupe alcénylène; Q représente un groupe phényle pouvant être substitué, ou un groupe benzoyle, etc. Ces composés présentent des effets neuroprotecteurs par induction de la calbindine D28kd, qui est l'une des protéines se liant à Ca<2+>.

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