Aminophenylsulfonamide derivatives as hiv protease inhibitor

Details Aminophenylsulfonamide derivatives as hiv protease inhibitor Aminophenylsulfonamide derivatives as hiv protease inhibitor

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61K 31/635 (2006.01) A61P 31/12 (2006.01)

Patent

CA 2628540

The present invention concerns substituted aminophenylsulfonamide compounds and derivatives, their use as protease inhibitors, in particular as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. The present invention also concerns combinations of the present substituted aminophenylsulfonamide compounds and derivatives with another anti-retroviral agent. It further relates to their use in assays as reference compounds or as reagents.

L'invention concerne des composés aminophénylsulfonamide substitués et leur dérivés, leur utilisation en tant qu'inhibiteurs de protéase, en particulier en tant qu'inhibiteurs de protéase du VIH à large spectre, leurs procédés de préparation ainsi que des compositions pharmaceutiques et des kits diagnostiques les comprenant. L'invention concerne également des combinaisons desdits composés aminophénylsulfonamide substitués et leur dérivés avec un autre agent antirétroviral. L'invention concerne en outre l'utilisation desdits composés dans des analyses en tant que composés de référence ou en tant que réactifs.

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