Aminophosphonic acid derivative, salt thereof, and modulator...

Details Aminophosphonic acid derivative, salt thereof, and modulator... Aminophosphonic acid derivative, salt thereof, and modulator...

C - Chemistry, Metallurgy

07

F

C07F 9/09 (2006.01) A61K 31/661 (2006.01) A61K 31/662 (2006.01) A61P 1/04 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07F 9/38 (2006.01) C07F 9/40 (2006.01)

Patent

CA 2515574

Aminophosphonic acid derivatives represented by the general formula (1) (such as 2-amino-5-[4-(3-benzyloxyphenyl-thio)-2-chlorophenyl]-2- methylpentylphosphonic acid mono-esters) exhibit excellent modulatory activity on S1P receptor and are reduced in adverse reaction.

L'invention concerne des dérivés d'acide aminophosphonique représentés par la formule générale (I) (telle que des monoesters d'acide 2-amino-5-[4-(3-benzyloxyphényl-thio)-2-chlorophényl]-2-méthylpentylphosphonique) exhibant une activité modulatoire excellente sur un récepteur S1P et des effets secondaires réduits.

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