C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/155 (2006.01) A61K 31/4985 (2006.01) A61K 31/5025 (2006.01) A61K 31/519 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 401/04 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01)
Patent
CA 2582447
The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase- IV enzyme is involved.
La présente invention concerne de nouvelles aminopipéridines substituées. Ces aminopipéridines sont des inhibiteurs de la dipeptidyle peptidase-IV (<= inhibiteurs DPP-IV >=) et sont utiles pour letraitement ou la prévention de maladies dans lesquelles la dipeptidyle peptidase-IV est impliquée, telles que le diabète et plus précisément le diabète de type 2. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et l'utilisation de ces composés et de ces compositions pour la prévention ou le traitement de ces maladies dans lesquelles la dipeptidyle peptidase-IV est impliquée.
Cox Jason M.
Edmondson Scott D.
Harper Bart
Weber Ann E.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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