Aminopiperidines for use as glyt-1 inhibitors

Details Aminopiperidines for use as glyt-1 inhibitors Aminopiperidines for use as glyt-1 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) A61K 31/4545 (2006.01) A61P 25/00 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2406652

Described herein are compounds having general formula (I), wherein groups R1, R2, R3, Ar1, Ar2, Ar3, X, Y, p and n are as defined in the specification, and a salt, solvate and hydrate thereof. Such compounds inhibit glycine transport (or reuptake) via the GlyT-1 transporter, or are precursors (for example, pro- drugs) of such compounds and, thus, are useful in the treatment of schizophrenia, as well as other CNS-related disorders such as dementia, Alzheimer's disease, attention deficit disorder and depression.

L'invention concerne des composés de formule générale (I), dans laquelle R¿1?, R¿2?, R¿3?, Ar¿1?, Ar¿2?, Ar¿3?, X, Y, p et n ont la définition indiquée dans la description, ainsi qu'un sel, un solvate et un hydrate de ces composés. Ces composés inhibent le transport (ou la réabsorption) de la glycine par l'intermédiaire du transporteur GlyT-1, ou constituent des précurseurs (par exemple des promédicaments) de ces composés et servent par conséquent au traitement de la schizophrénie ainsi que des troubles liés au système nerveux central, tels que la démence, la maladie d'Alzheimer, le déficit de l'attention et la dépression.

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