C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/279.25, 260/
C07D 333/50 (2006.01) C07D 333/54 (2006.01) C07D 333/78 (2006.01) C07D 333/80 (2006.01) C07D 409/12 (2006.01)
Patent
CA 1158643
ABSTRACT OF THE DISCLOSURE New derivatives of 1-aminopropan-2-ol which are useful in the treatment and control of cardiac disorders in warm-blooded mammals correspond to the formulae: Image Image E-isomer (I) Z-isomer (II) wherein R1 and R2, which may be the same or different, are hydrogen atoms; straight-chained or branched alkyl radicals containing up to 8 carbon atoms; monocyclic cycloalkyl radicals containing up to 12 carbon atoms or adamantyl radicals; .alpha.,.alpha.-dialkylpropynyl radicals, each alkyl moiety of which contains up to 4 carbon atoms; phenylalkyl radicals, the alkyl moiety of which contains up to 4 carbon atoms and the phenyl nucleus of which is optionally substituted one or more times by alkoxy radicals containing up to 4 carbon atoms; pyridylalkyl radicals containing up to 4 carbon atoms in the alkyl moiety; or dialkylaminoalkyl radicals, each alkyl moiety of which contains up to 4 carbon atoms; or R1 and R2, to- gether with the nitrogen atom to which they are attached, form a pyrrolidino, morpholino, piperidino or piperazino radical, the latter optionally being substituted on the other nitrogen atom by an alkyl radical containing up to 4 carbon atoms or by a benzyl radicals and n is 1, 2 or 3; and the addition salts thereof with pharmaceutically- acceptable inorganic or organic acids.
367082
Courregelongue Jean
Maffrand Jean-Pierre
Goudreau Gage Dubuc
Sanofi
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