Aminopropanol derivatives

Details Aminopropanol derivatives Aminopropanol derivatives

C - Chemistry, Metallurgy

07

D

260/319

C07D 209/04 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 209/42 (2006.01)

Patent

CA 1051002

ABSTRACT OF THE DISCLOSURE New aminopropanol derivatives and their process of preparation are provided of the formula (I) Image (I) wherein R is a lower alkyl, cyclo-lower-alkyl or lower-alkyl- thio-lower-alkyl radical, R1 is a hydrogen atom or a lower alkyl, hydroxy-lower-alkyl, pivaloyloxy- lower-alkyl, lower-alkoxy-lower-alkyl, lower-alkoxycarbonyl or carboxyl radical or the radical -CONR3R4, in which R3 and R4 can be the same or different and represent hydrogen atoms or lower alkyl radicals, and R2 is a lower alkyl, hydroxy-lower- alkyl, lower-alkoxy-lower-alkyl or pivaloyloxy-lower-alkyl radical or, when R is a lower-alkylthio-lower-alkyl radical or R1 is a pivaloyloxy-lower-alkyl radical, R2 can also be a hydrogen atom and the pharmacologically compatible acid addition salts thereof; the novel derivatives as well as the pharmacologically compatible acid addition salts thereof, bring about an inhibition of the adrenogenic .beta.-recoptors and can, therefore, be used for the treatment or prophylaxis of cardiac and circulatory diseases.

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