Aminopropanol derivatives

Details Aminopropanol derivatives Aminopropanol derivatives

C - Chemistry, Metallurgy

07

D

260/265.9

C07D 241/36 (2006.01) C07D 241/38 (2006.01) C07D 241/44 (2006.01) C07D 401/00 (2006.01)

Patent

CA 1145338

ABSTRACT The present invention provides aminopropanol derivatives of the general formula:- Image (I) wherein R1 and R2, which can be the same or different, are hydrogen atoms or lower alkyl radicals or together represent an alkylene radical, R3 is a hydrogen atom or an acyl radical, A is one of the following structural elements: Image , Image Image , or in which R4 is a hydrogen atom or a lower alkyl radical, which is optionally substituted by hydroxyl, halogen, phenyl or alkylthio and R5 and R6, which can be the same or different, are lower alkyl radicals, and B is an alkyl- amino radical which optionally carries a phenyl and/or phenoxy radical, which can be substituted one or more times by halogen, hydroxyl, lower alkyl, lower acyl, lower alkylthio, acylamino, aminocarbonyl, lower alkoxy, lower alkenyloxy, phenoxy, lower alkenyl, lower alkyl- sulphonyl, lower alkylsulphinyl or haloalkyl, or is an an aryl- or heteroaryloxymethylpiperidine radical, which is optionally substituted onr or more times by halogen, hydroxyl or lower alkyl, which optionally carries a hydroxyl or carboxamido substituent, a lower alkoxy, lower acyl, amino, carboxamido, lower alkylcarbonylamido or lower alkylsulphonylamino radical; and the pharma- cologically acceptable salts thereof. The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them and is also concerned with the use thereof as pharmaceuticals for combating cardiac and circulatory diseases.

352092

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