Aminopropanol derivatives of substituted 2-hydroxy-...

C - Chemistry – Metallurgy – 07 – D

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C07D 207/335 (2006.01) C07D 207/333 (2006.01) C07D 213/50 (2006.01) C07D 231/12 (2006.01) C07D 307/46 (2006.01) C07D 333/22 (2006.01) C07D 409/12 (2006.01)

Patent

CA 1233465

- 19 - Abstract of the Disclosure: Aminopropanol derivatives of the formula Image I where R1 and R2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxy- alkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R1 and R2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hyd- roxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and- Image is thien-2-yl, thien-3-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, fur-2-yl, 1-alkylpyrr- 2-yl, 1-alkylpyrr-3-yl or 1-alkylpyrazol-4 yl, alkyl being of 1 to 3 carbon atoms, and their physiologically tolerated addition salts with acids, processes for their preparation, and antiarrhythmic agents containing these compounds.

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