Aminopyrazole compounds and use as chk1 inhibitors

Details Aminopyrazole compounds and use as chk1 inhibitors Aminopyrazole compounds and use as chk1 inhibitors

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61P 35/00 (2006.01) C07D 231/38 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2532231

Described herein are aminopyrazole compounds of formula (I), wherein R1, R2, L and Ar are as defined in the specification. Such compounds are capable of modulating the activity of a checkpoint kinase and methods for utilizing such modulation to treat cell proliferative disorders. Also described are pharmaceutical compositions containing such compounds. Also described are the therapeutic or prophylactic use of such compounds and compositions, and methods of treating cancer as well as other diseases associated with unwanted cellular proliferation, by administering effective amounts of such compounds in combination with anti-neoplastic agents.

L'invention concerne des composés d'aminopyrrazoles de formule I, dans laquelle R?1¿, R?2¿, L et Ar ont la définition donnée dans la spécification. Ces composés sont capables de moduler l'activité d'une kinase de repère (CHK). L'invention concerne également des méthodes d'utilisation de cette modulation pour traiter des troubles de la prolifération cellulaire, des compositions pharmaceutiques qui contiennent ces composés, l'utilisation thérapeutique ou prophylactique de ces composés et de ces compositions, et des méthodes de traitement du cancer et d'autres maladies associées à une prolifération cellulaire indésirable par administration de quantités efficaces de ces composés en combinaison avec des agents anti-néoplastiques.

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