Aminopyrazole derivatives as gsk-3 inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 231/40 (2006.01) A61K 31/415 (2006.01) A61P 25/00 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2547283

The present invention provides compounds of formula (I) the stereoisomers and prodrugs thereof, and the pharmaceutically acceptable salts of the compounds, stereoisomers, and prodrugs, wherein R1, R2, and R3 are as defined herein; pharmaceutical compositions thereof; combinations thereof; and uses thereof in the treatment of, inter alia, conditions, diseases, and symptoms including, inter alia, Alzheimer's Disease, cancer, dementia, depression, diabetes, hair loss, schizophrenia, and stroke.

L'invention concerne des composés de la formule (I), leurs stéréoisomères et promédicaments, ainsi que les sels pharmaceutiquement acceptables de ces composés, stéréoisomères et promédicaments, R?1¿, R?2¿ et R?3¿ étant tels que définis dans la description; leurs compositions pharmaceutiques; leurs associations; et leurs utilisations dans le traitement, entre autres, des pathologies, maladies et symptômes englobant, entre autres, la maladie d'Alzheimer, le cancer, la démence, la dépression, le diabète, la chute des cheveux, la schizophrénie et les accidents vasculaires cérébraux.

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