Aminopyridine derivatives

Details Aminopyridine derivatives Aminopyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 417/14 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) C07D 213/74 (2006.01) C07D 401/02 (2006.01) C07D 401/12 (2006.01) C07D 405/02 (2006.01) C07D 405/12 (2006.01) C07D 409/02 (2006.01) C07D 409/12 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2249222

Compounds of general formula [I] or pharmaceutically acceptable salts thereof; and agents for the treatment of hyperphagia, obesity or diabetes, comprising the same as the active ingredient wherein Ar1 is aryl or hetero-aryl which may be substituted with a radical selected from the group consisting of lower alkyl, lower hydroxyalkyl, lower alkylene and -NR a R b ; R1 is hydrogen or lower alkyl; R2 and R3 are each independently lower alkyl, or alternatively R2 and R3 are united to form alkylene which may be interrupted by oxygen or sulfur and may be substituted with one or two lower alkyl radicals; R4 is hydrogen or lower alkyl which may be substituted with a radical selected from the group consisting of hydroxyl, amino, carbamoyl and lower alkoxycarbonyl; Ar2 is aryl or hetero-aryl which may be substituted with a radical selected from the group consisting of halogeno, hydroxyl, lower alkyl, lower haloalkyl, lower alkoxy, lower alkylthio, lower hydroxyalkyl, lower alkoxy lower alkyl, -NR c Rc d and -NR e-CO-NR i R g ; and W is oxygen, sulfur, -CHR j- or -NR k-.

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