Aminopyridine derivatives as selective dopamine d3 agonists

Details Aminopyridine derivatives as selective dopamine d3 agonists Aminopyridine derivatives as selective dopamine d3 agonists

C - Chemistry, Metallurgy

07

D

C07D 213/73 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61K 31/5377 (2006.01) A61P 15/00 (2006.01) A61P 25/00 (2006.01) C07D 401/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2567935

The present invention provides for compounds of formula (I) which are a class of dopamine agonists, more particularly a class of agonists that are selective for D3 over D2. These compounds are useful for the treatment and/or prevention of sexual dysfunction, for example female sexual dysfunction (FSD), in particular female sexual arousal disorder (FSAD), hypoactive sexual desire disorder (HSDD; lack of interest in sex), female orgasmic disorder (FOD; inability to achieve orgasm); and male sexual dysfunction, in particular male erectile dysfunction (MED). Male sexual dysfunction as referred to herein is meant to include ejaculatory disorders such as premature ejaculation, anorgasmia (inability to achieve orgasm) or desire disorders such as hypoactive sexual desire disorder (HSDD; lack of interest in sex). These compounds are also useful in treating neuropsychiatric disorders and neurodegenerative disorders.

Cette invention concerne des composés représentés par la formule (I), qui font partie d'une classe d'agonistes de la dopamine et, plus particulièrement, d'une classe d'agonistes sélectifs pour la dopamine D3 sur D2. Ces composés sont utiles pour le traitement et/ou la prévention des dysfonctionnements sexuels, tels que les dysfonctionnements sexuels chez la femme (FSD), notamment le trouble de l'excitation sexuelle chez la femme (FSAD), la baisse du désir sexuel (HSDD), le trouble orgasmique chez la femme (FOD ; incapacité d'atteindre l'orgasme) ; et les dysfonctionnements sexuels chez l'homme, notamment le trouble de l'érection (MED). Les dysfonctionnements sexuels chez l'homme font référence notamment aux troubles de l'éjaculation, tels que l'éjaculation précoce, l'anorgasmie (incapacité d'atteindre l'orgasme) ou les troubles du désir, tels que la baisse du désir sexuel (HSDD). Ces composés sont également utiles pour traiter les troubles neuropsychiatriques et les troubles neurodégénératifs.

Affiliated with

Also associated with

Rating

Aminopyridine derivatives as selective dopamine d3 agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aminopyridine derivatives as selective dopamine d3 agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aminopyridine derivatives as selective dopamine d3 agonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1684857